German Research Foundation (DFG)‏

Kinetochore oscillations in mitotic metaphase

During mitosis, sister chromatids connect to microtubules extending from the opposite spindle poles via kinetochores, protein complexes on the chromosome. When a pair of sister kinetochores establishes this configuration, they oscillate around the equatorial plane of the spindle, and the amplitude of these oscillations depends on kinesin-8 motors. During the oscillations sister kinetochores are separated due to tension, which has been proposed to regulate the spindle assembly checkpoint. The aim of this project is to study the mechanism of kinetochore oscillations.

Research area: Cell biology
Researcher: Iva Tolić
Host Institution: Ruđer Bošković Institute, Zagreb
Project: Kinetochore oscillations in mitotic metaphase
DFG funding: € 255,950 for the whole team